Searchable abstracts of presentations at key conferences in endocrinology

ea0065p233 | Metabolism and Obesity | SFEBES2019

L-Phenylalanine simulates the secretion of pancreatic hormones via vagal CaSR

Norton Mariana , Cork Simon C , Roberts Anna , Patel Yateen , Cheng Sijing , Hansford Robert , Cao Ye , Hanyaloglu Aylin , Chang Wenhan , Murphy Kevin G

High protein diets are effective at promoting weight loss and stimulating the secretion of pancreatic hormones. Understanding the mechanisms underlying these effects may highlight new potential therapeutic targets. The calcium sensing receptor (CaSR) is stimulated by calcium and plays a critical role in calcium homeostasis. However, it is also found in many tissues unrelated to calcium regulation. CaSR activity can be modulated by aromatic amino acids, most potently by ...